CSF Leak: Essential Guide to Symptoms, Causes, Diagnosis & Treatment Options


Introduction

A cerebrospinal fluid (CSF) leak is an often-overlooked medical condition that can cause life-altering symptoms like severe headaches, neck pain, and dizziness. These leaks occur when the fluid surrounding the brain and spinal cord escapes through a tear in the dura, the protective membrane. While CSF leaks can result from trauma, medical procedures, or spontaneous causes, they are frequently misdiagnosed, leaving patients without proper treatment.

This page explores the causes, symptoms, and treatments for CSF leaks, offering vital information to help patients and carers understand this condition and seek the care they need. Whether you’re experiencing symptoms or supporting a loved one, this guide is here to provide clarity and support.

A short video about CSF leaks

This video explains the main types of CSF leaks and how they can be caused, from iatrogenic leaks due to medical procedures to spontaneous leaks such as dural tears.

Thank you for watching! Now that you’ve learned about the main types of CSF leaks, read on to explore more in-depth information about this condition, including symptoms, causes, and treatment options.

A cranial cerebrospinal fluid (CSF) leak occurs when CSF escapes through a defect in the skull, often resulting in fluid draining from the nose (CSF rhinorrhoea) or ear (CSF otorrhoea). These leaks can lead to various symptoms, including hearing loss, a metallic or salty taste in the mouth, or a reduced sense of smell.

Causes of Cranial CSF Leaks
Cranial leaks are typically caused by:

Diagnosing Cranial CSF Leaks
Cranial leaks differ from spinal CSF leaks, as they generally do not cause the low-pressure symptoms associated with spinal leaks. Diagnosis often involves imaging, such as thin-sliced CT, head MRI, and CT cisternography, where a contrast dye is injected to visualise CSF flow and pinpoint the leak. Additionally, collecting and testing the draining fluid can confirm it is CSF.

Treatment Options for Cranial CSF Leaks
Cranial CSF leaks require prompt attention due to the risk of meningitis, as the open connection between the brain and the nasal or ear cavities can allow bacteria to enter.

Visit our Cranial Leak Resource Hub for more…

Lumbar Punctures (Spinal Taps): Often performed to measure intracranial pressure or to collect CSF for diagnostic testing, lumbar punctures can sometimes create a small hole in the dura, leading to a CSF leak. In most cases, these leaks heal on their own, but some may persist and require further treatment.

Epidural Injections: Administered for pain relief, particularly during childbirth, epidural injections involve placing a needle close to the dura. Accidental puncture of the dura during this procedure can lead to an iatrogenic CSF leak.

Learn More About Iatrogenic CSF Leaks
If you’ve experienced a CSF leak following a medical procedure, our dedicated Resource Hub for Iatrogenic CSF leaks offers practical tools, advocacy support, and detailed guidance to help you navigate your care.

Explore the Iatrogenic Needle Puncture Resource Hub here.

Head Injury or Trauma: Even minor head injuries or falls can create small tears in the dura, leading to a CSF leak.

Lifting Heavy Objects: Strenuous activities, such as lifting heavy items, can temporarily increase intracranial pressure, potentially causing or worsening a leak in individuals with pre-existing weaknesses in the dura.

Increased Intracranial Pressure (Idiopathic Intracranial Hypertension or IIH): In some individuals, raised intracranial pressure can place stress on the dura, resulting in a spontaneous CSF leak.

Bone Spurs (Osteophytes): Bony growths, particularly in the spine, can press against or puncture the dura, leading to a leak. Osteophytes are more common in people with degenerative spine conditions, which can increase the likelihood of spontaneous CSF leaks.

Dural Abnormalities Around Nerve Roots: Structural abnormalities in the dura mater near the nerve roots in the spine, sometimes congenital or due to connective tissue disorders, can make these areas more susceptible to tears and leaks.

Just some of the symptoms experienced…

Brain MRI

Bern Score:

Bern score table

Full Spine MRI

Negative MRI

We often hear, “My doctor wants me to have a lumbar puncture to check my intracranial pressure (ICP) for signs of a CSF leak.”

Please think carefully before proceeding.

While a lumbar puncture can measure ICP, it is not a reliable diagnostic tool for detecting CSF leaks. Here’s why:

If a CSF leak is suspected, consult with a specialist knowledgeable about alternative diagnostic methods and imaging techniques specifically suited for CSF leak detection.

photo credit: Siemens Healthineers
T1/2 Ventral Dural Defect located on CTM
CSF-Venous Fistula at T9/10 located on CTM

Conservative Approach:

Before your neurology referral has gone through, if you are suspect of having a CSF leak, you should be told to (or just do this yourself):

Some patients may be offered non-targeted blood patches, sometimes referred to as a “blind” blood patch. However, this term can be misleading, as it suggests the procedure is performed without imaging guidance, which is generally not recommended. Non-targeted patches should only be considered if the procedure is done very early in the course of symptoms. If the patient has had SIH confirmed via Brain MRI, don’t wait for the spine to be scanned; if you are within three months of onset of symptoms, a non-targeted epidural blood patch should be considered.

These patches are typically administered in the lumbar region, as this site is considered safer and more accessible, being further away from the spinal cord. The procedure can serve two purposes: it may help alleviate symptoms in approximately 50% of cases or act as a diagnostic tool to assess whether symptoms improve. A high-volume patch – defined as greater than 20ml of blood – can create pressure against the spinal cord, thereby increasing the pressure above that point.

Note: Blood patches are not effective for sealing venous fistulas.

Risks of Having a Blood Patch

Like any medical procedure, an epidural blood patch carries certain risks and potential after-effects. It’s important to be informed about these before undergoing the procedure. The following are some of the associated risks:

Given these risks, it’s essential to discuss them thoroughly with your healthcare provider before proceeding with an epidural blood patch. Understanding the potential outcomes can help you make an informed decision about your treatment options and ensure that you are adequately monitored during and after the procedure.

Tisseel is the most commonly used glue.

The exact mechanism by which fibrin glue works remains somewhat unclear. While we understand the chemical properties of the glue, it is still uncertain whether it adheres directly to the dura mater, triggers an inflammatory healing response in the body, effectively stops the flow of cerebrospinal fluid at the site of the defect, or, in the case of venous fistulas, blocks the flow from the affected vein. It is likely that the effectiveness of fibrin glue arises from a combination of these factors.

Fibrin Glue Injection at T10 nerve root

The injection of fibrin glue is performed under CT or fluoroscopy guidance while the patient is awake and made comfortable with local anaesthetic. A needle is inserted through the skin, and its position is confirmed using air or a small amount of contrast. A local anaesthetic is administered at the nerve root, and typically, between 2 to 6 ml of glue is injected. The fibrin glue remains in the body for a maximum of 4 to 6 weeks before being absorbed.

Fibrin Glue Injection at T9/10 venous fistula

Regarding the effectiveness of fibrin glue, high-quality data is limited; however, anecdotal evidence suggests that it can be reasonably successful, particularly in acute cases rather than chronic ones. Chronic cases refer to patients who have been experiencing leaks for more than a year. Nevertheless, even in long-standing cases, fibrin glue can be a suitable initial procedure, especially for addressing venous fistulas. The procedure itself is generally considered straightforward and well-tolerated by patients, though repeat treatments may be necessary.

After-care advice following epidural blood patch or fibrin glue injection.

There is little attention given in the medical literature about after-care advice following epidural blood patching or fibrin glue injections, and the advice given can vary between centres, however, these are our top tips:

First 24 hours: Rest. Avoid straining.
Lie flat or slightly propped.

Next 6 weeks: Avoid bending, lifting and twisting. Do not lift anything over 5lbs. Avoid coughing and sneezing with your nose or mouth closed. Avoid straining on the toilet – help yourself – use laxatives to keep your stools soft and moving. Avoid anything that will increase your systems pressure: no balloon blowing, no playing of wind or brass instruments.
Avoid caffeine, salts and other triggers which could potentially increase your intracranial pressure.

We understand that many individuals enjoy exercising and frequently ask when they can resume physical activity. While there are currently no specific evidence-based guidelines or case studies available on this topic, it is generally recommended to avoid all intentional exercise for the first month following your procedure.

During months 2 to 3, you may gradually start to incorporate some low-impact exercises into your routine. However, it is crucial to avoid strenuous activities involving bending, lifting, and twisting for several months.

It’s important to remember that the dura can take up to a year to fully heal and recover. Therefore, even if you start to feel well, it’s essential to take care of yourself and avoid overexertion too soon. Listening to your body and proceeding with caution will help support your healing process.


There are different techniques surgeons use to repair the dura. You’ll usually have plenty of opportunity to talk the procedure through with your surgeon. Some surgeons use laminectomy’s, whilst others prefer to use a laminoplasty technique.


For the repair of a ventral spinal cerebrospinal fluid (CSF) leak in the thoracic or lumbar spine, the surgical approach is typically from the posterior aspect of the spine. A 10 to 15-centimetre incision is made, followed by either a full or hemilaminectomy. A full laminectomy involves the removal of both laminae, which constitute the roof of the spinal canal at the targeted vertebrae. In contrast, a hemilaminectomy entails the removal of only one lamina from each vertebra, allowing for the preservation of most of the bone. Depending on the location of the leak and the access required, the patient may require a double laminectomy or a more extensive one-and-a-half laminectomy.

Once the dura mater is exposed, it is carefully opened to locate and repair the defect. Throughout the procedure, the nerve pathways are meticulously monitored, providing the surgeon with continuous feedback regarding the integrity of the spinal cord and surrounding nerves.

The specific methods and materials used to repair the defect are determined during the surgery, as they depend on the size of the dural tear and whether any bony fragments are protruding through the dura. While most bony spicules will have been absorbed by this stage, bone removal will only occur if absolutely necessary. Small tears can often be repaired with a single stitch, whereas larger tears may require the use of a dural substitute (such as DuraGuard) or a muscle graft. The surgeon should discuss their planned technique with you beforehand, ensuring that you are comfortable with the approach being taken.


For the repair of a ventral spinal cerebrospinal fluid (CSF) leak in the cervical spine, the surgical approach typically involves an anterior approach. An incision is made in the front of the neck, allowing the surgeon to access the cervical spine directly. The specific length of the incision may vary depending on the location of the leak and the necessary access.

During the procedure, the surgeon may need to retract the trachea and oesophagus to reach the affected vertebrae. Once access is obtained, the appropriate vertebrae are identified, and the anterior aspect of the spine is exposed. If necessary, the surgeon may remove any bony structures, such as osteophytes, that could be contributing to the leak.

The dura mater is then carefully opened to locate the site of the CSF leak. Continuous monitoring of the nerve pathways occurs throughout the operation, providing the surgeon with real-time feedback on the condition of the spinal cord and surrounding nerves.

The method of repair will depend on the size and nature of the dural tear. Small tears can often be closed with sutures, while larger defects may require the use of a dural substitute or graft to ensure an effective seal. If there are any bony fragments involved, they will be addressed as necessary. The surgeon will discuss the planned technique with you prior to the procedure, ensuring you are informed and comfortable with the approach to be taken.


For the repair of a lateral spinal cerebrospinal fluid (CSF) leak due to a nerve root sleeve tear, the surgical approach is posterior. The procedure begins with a careful incision over the affected area of the spine, usually around 10cm in length, allowing access to the targeted vertebrae.

Once the incision is made, the surgeon performs a laminectomy to expose the relevant nerve roots and surrounding structures. This may involve removing a portion of the lamina to gain adequate visibility and access to the nerve root sleeve where the tear has occurred.

During the operation, the surgeon carefully isolates the affected nerve root and identifies the site of the CSF leak. Continuous monitoring of the nerve pathways is conducted throughout the procedure, providing real-time feedback on the integrity of the spinal cord and nearby nerves.

The repair technique employed will depend on the size and location of the tear. Smaller tears may be sutured directly, while larger tears may require the use of a dural patch or graft to effectively seal the defect. Additionally, any contributing factors, such as bone spurs or other abnormalities that could be causing irritation or pressure on the nerve root, will be addressed as needed.

The surgeon will discuss the specific repair technique to be used during the operation, ensuring that you understand the approach and feel comfortable with the planned procedure.


The surgical management of venous fistulas typically involves two primary approaches, tailored to the specific characteristics of the fistula and the patient’s anatomy.

1. Direct Clipping of the Fistulous Connection:
In cases where the fistulous connection is accessible, the surgeon may opt to clip the abnormal vessel directly. This procedure aims to occlude the communication between the veins, effectively stopping the flow of blood that contributes to the fistula. The decision to use this method will depend on the fistula’s location, size, and the surrounding anatomical structures. During the operation, careful dissection is performed to identify the exact point of the fistula, ensuring minimal disruption to adjacent tissues.

2. Clipping or Ligation of the Non-Eloquent Nerve Root:
If direct clipping of the fistulous connection is not feasible due to its position or other factors, the surgeon may consider clipping or ligating a non-eloquent nerve root associated with the fistula. Non-eloquent nerve roots are those that do not control critical functions, allowing the surgeon to prioritise the resolution of the fistula without compromising essential nerve pathways. This approach can effectively reduce or eliminate the venous flow contributing to the fistula while maintaining the integrity of surrounding neural structures.

Throughout the procedure, the surgical team employs careful monitoring and imaging techniques to ensure precision in addressing the fistula and to minimise potential complications. The choice between these two techniques will be influenced by the specific clinical scenario, and the surgeon will discuss the rationale for the chosen approach with the patient prior to surgery.


Risks of having spinal surgery:

The surgical procedure carries inherent risks, including a 5% chance of total paralysis affecting the legs, bladder, and bowel. Additionally, there is an overall 10% risk of permanent neurological impairment, which may manifest as weakness or diminished sensation in the legs, potentially leading to long-term issues with bladder or bowel function. Many patients report a temporary exacerbation of arm and/or leg function post-surgery, although this is typically not severely debilitating.

As with any surgical intervention, there are also general risks to consider, such as infection, bleeding, and worsening pain. Anaesthesia-related complications may include blood clots in the legs or lungs, heart attacks, strokes, pneumonia, bladder infections, skin damage, and ulcers. Furthermore, there is a risk of nerve injury affecting other areas of the body, as well as potential threats to vision.



Prognosis

Prognosis

Overall, the prognosis for the majority of patients who receive appropriate treatment for CSF leaks is positive. Many individuals experience significant relief from their symptoms and can return to their daily activities. With advancements in medical techniques and therapies, the likelihood of successful intervention has increased.

However, it is important to note that a small percentage of patients may continue to face challenges, experiencing ongoing pressure issues and persistent symptoms despite receiving affective interventions. Factors such as the complexity of the leak, the duration of symptoms before treatment, and individual patient health can influence outcomes. Continuous follow-up care and a tailored approach to each patient’s needs are essential to optimise recovery and address any lingering issues effectively.


Rebound High Pressure

After successfully sealing the defect, some patients may experience headaches due to the body continuing to over-produce CSF even though the leak has resolved. It can take time for the body to recalibrate, and during this period, changes in intracranial pressure can lead to headaches that mimic those associated with high pressure. Patients often report that the pain is exacerbated when lying down and improves when sitting or standing. Additionally, some individuals may notice visual disturbances.

To manage these symptoms, medication may be prescribed to reduce CSF production. This treatment is typically temporary, lasting from a few days to a few weeks. However, in approximately 25-30% of cases, patients may continue to experience persistent pressure issues, indicating the need for ongoing management and monitoring.